In March, the City Council approved a set of restrictive zoning regulations that would allow up to four collectives to legally exist in eight of nine city council districts.
The restrictions on distances between dispensaries and houses, schools, churches and the like preclude any from being in council President Todd Gloria's district, which includes downtown, Hillcrest and North Park.
Until the city starts issuing the conditional use permits, all collectives in the city are considered illegal. The mayor's office said the permit process could cost applicants $100,000.
The city has been taking applications from prospective legal collective operators since April.
The first legal dispensary considered legal by the county recently opened for business near Gillespie Field.